AutoCAD engineering
Concept geometry, stage views and engineering drawings — a question turned into something you can inspect and measure. Fabrication readiness still requires validation.
Rosetta stone 04
Two Classes Open the Tap. Two Close the Drain.
Artemisinins, protease inhibitors, auranofin and the sulfur benzimidazoles are not four mechanisms. They are two halves of one circuit.
Opening the tap
Artemisinins deliver a peroxide bridge to ferrous iron, which tumours hoard; the resulting Fenton chemistry erupts into hydroxyl radicals at the metal. Protease inhibitors overload the endoplasmic reticulum — and oxidative protein folding generates one molecule of hydrogen peroxide for every disulfide bond formed, so packing the ER with unfolded protein turns the organelle into a peroxide generator.
Closing the drain
Auranofin, approved in 1985 for rheumatoid arthritis decades before anyone identified what it does, is an organogold complex that poisons thioredoxin reductase — the cell's primary peroxide drain. Disulfiram-copper does the same job. Neither adds an oxidant; they weld the outlet shut.
The shuttle
Sulfur-bearing benzimidazoles cycle an endogenous sulfide-sulfoxide-sulfone shuttle, draining reducing equivalents into the same pool. Four unrelated families, one quantity.
A prediction that can embarrass us
Sulfur-bearing members of the benzimidazole class carry a redox couple the benzoyl members lack entirely. Our reading says the two halves separate on a redox-sensitive readout. The conventional account gives no reason to expect any such split. Tens of thousands of dollars, on compounds already sitting on shelves. If the split does not appear, the reading is wrong.
✦ / The field we intend to own
From engineering drawings to molecular blueprints.
One discipline runs underneath all of it: computational engineering — designing the thing completely, and proving out what you can, before anyone cuts metal or runs a reaction. It is the same craft whether the object is a bracket or a molecule. Only the units change.
Computational engineering · one continuum
Structure and materials
The lattice between the two worlds: geometry that has to obey physics before it is worth costing, let alone building.
Biotechnology & molecular research
The same discipline applied to chemistry — scaffolds, conjugates and the design rationale for why a given structure should be made before anyone makes it.
Full RDKit molecular blueprints
Every structure parsed, sanitised and reported with its computed property set: isomeric SMILES, mass, lipophilicity, polar surface area, stereocentres. Computed, never quoted.
Our intention is plain: to own this field — computational engineering from the drawing to the molecule. Not by holding patents, but by being the group that does the work in the open, publishes its own corrections, and is the best in the world at deciding what is worth building next.
Computational designs only. Nothing described here has been synthesised, assayed or administered, and every property is a computed descriptor rather than a measurement. Fabrication and clinical readiness require validation that happens outside this factory.