AutoCAD engineering
Concept geometry, stage views and engineering drawings — a question turned into something you can inspect and measure. Fabrication readiness still requires validation.
Rosetta stone 03
Broccoli Fits No Pocket Either
Sulforaphane does not dock. It chemically modifies a sensor protein — and that is a different kind of mechanism.
What it actually does
Sulforaphane is an isothiocyanate from cruciferous vegetables. It alkylates reactive low-pKa cysteine thiolates on KEAP1, the sensor that otherwise marks NRF2 for degradation. Modify the sensor and the downstream antioxidant response programme runs. There is no binding pocket in that sentence — it is covalent chemistry on a reactive residue.
Same grammar as peroxide
Both act on reactive cysteines. One oxidises, one alkylates, and neither needs a complementary shape. Two agents from completely different places — a vegetable and a metabolite — speaking the same chemical language to the same class of residue.
Why it belongs beside a wormer
Because the list only looks absurd under the lock-and-key lens. Under the field-coupling lens — a wormer, an antimalarial, a gold arthritis salt, baking soda, broccoli, a magnet — every one is doing something to the same cellular quantity. The absurdity is evidence that the first lens is the wrong one, not that the list is wrong.
✦ / The field we intend to own
From engineering drawings to molecular blueprints.
One discipline runs underneath all of it: computational engineering — designing the thing completely, and proving out what you can, before anyone cuts metal or runs a reaction. It is the same craft whether the object is a bracket or a molecule. Only the units change.
Computational engineering · one continuum
Structure and materials
The lattice between the two worlds: geometry that has to obey physics before it is worth costing, let alone building.
Biotechnology & molecular research
The same discipline applied to chemistry — scaffolds, conjugates and the design rationale for why a given structure should be made before anyone makes it.
Full RDKit molecular blueprints
Every structure parsed, sanitised and reported with its computed property set: isomeric SMILES, mass, lipophilicity, polar surface area, stereocentres. Computed, never quoted.
Our intention is plain: to own this field — computational engineering from the drawing to the molecule. Not by holding patents, but by being the group that does the work in the open, publishes its own corrections, and is the best in the world at deciding what is worth building next.
Computational designs only. Nothing described here has been synthesised, assayed or administered, and every property is a computed descriptor rather than a measurement. Fabrication and clinical readiness require validation that happens outside this factory.